Dr. Kenzou Tenma, an elite neurosurgeon recently engaged to his hospital director's daughter, is well on his way to ascending the hospital hierarchy. That is until one night, a seemingly small event changes Dr. Tenma's life forever. While preparing to perform surgery on someone, he gets a call from the hospital director telling him to switch patients and instead perform life-saving brain surgery on a famous performer. His fellow doctors, fiancée, and the hospital director applaud his accomplishment; but because of the switch, a poor immigrant worker is dead, causing Dr. Tenma to have a crisis of conscience. So when a similar situation arises, Dr. Tenma stands his ground and chooses to perform surgery on the young boy Johan Liebert instead of the town's mayor. Unfortunately, this choice leads to serious ramifications for Dr. Tenma—losing his social standing being one of them. However, with the mysterious death of the director and two other doctors, Dr. Tenma's position is restored. With no evidence to convict him, he is released and goes on to attain the position of hospital director. Nine years later when Dr. Tenma saves the life of a criminal, his past comes back to haunt him—once again, he comes face to face with the monster he operated on. He must now embark on a quest of pursuit to make amends for the havoc spread by the one he saved. [Written by MAL Rewrite]

Within the domed city of Romdo lies one of the last human civilizations on Earth. Thousands of years ago, a global ecological catastrophe doomed the planet; now, life outside these domes is virtually impossible. To expedite mankind's recovery, "AutoReivs," humanoid-like robots, have been created to assist people in their day-to-day lives. However, AutoReivs have begun contracting an enigmatic disease called the "Cogito Virus" which grants them self-awareness. Re-l Mayer, granddaughter of Romdo's ruler, is assigned to investigate this phenomenon alongside her AutoReiv partner Iggy. But what begins as a routine investigation quickly spirals into a conspiracy as Re-l is confronted by humanity's darkest sins. Elsewhere in Romdo, an AutoReiv specialist by the name of Vincent Law must also face his demons when surreal events begin occurring around him. Re-l, Iggy, Vincent, and the child AutoReiv named Pino, will form an unlikely faction as they struggle to uncover Romdo's mysteries and ultimately, discover the true purpose of the mythical beings called "Proxies." [Written by MAL Rewrite]

In Tokyo's downtown district of Ikebukuro, amidst many strange rumors and warnings of anonymous gangs and dangerous occupants, one urban legend stands out above the rest—the existence of a headless "Black Rider" who is said to be seen driving a jet-black motorcycle through the city streets. Mikado Ryuugamine has always longed for the excitement of the city life, and an invitation from a childhood friend convinces him to move to Tokyo. Witnessing the Black Rider on his first day in the city, his wishes already seem to have been granted. But as supernatural events begin to occur, ordinary citizens like himself, along with Ikebukuro's most colorful inhabitants, are mixed up in the commotion breaking out in their city. [Written by MAL Rewrite]

A series of unfortunate events has led Makoto "Edamame" Edamura to adopt the life of crime—pickpocketing and scamming others for a living. However, after swindling a seemingly clueless tourist, Makoto discovers that he was the one tricked and, to make matters worse, the police are now after him. While making his escape, he runs into the tourist once again, who turns out to be a fellow con man named Laurent Thierry, and ends up following him to Los Angeles. In an attempt to defend his self-proclaimed title of "Japan's Greatest Swindler," Makoto challenges his rival to determine the better scammer. Accepting the competition, Laurent drops them off outside a huge mansion and claims that their target will be the biggest mafia boss on the West Coast. Jumping from city to city, Great Pretender follows the endeavors of Makoto alongside the cunning Laurent and his colorful associates in the world of international high-stakes fraud. Soon, Makoto realizes that he got more than what he bargained for as his self-declared skills are continually put to the test. [Written by MAL Rewrite]